Grobstein

On June 4, 2003, two outbreaks of a highly virulent strain of the bacterium were reported in Montreal and Calgary. The death count was estimated to be between 36 and 89, with approximately 1,400 cases in 2003.
C. difficile infections continued to be a problem in the Quebec health care system in late 2004.

As of March 2005, it had spread into the Toronto, Ontario area, hospitalizing 10 people. One died while the others were being discharged.

On October 27, 2006, 9 deaths were attributed to the bacterium in Quebec.

On November 18, 2006, the bacterium was reported to have been responsible for 12 deaths in Quebec. The 12th reported death was only two days after the St. Hyacinthe's Honoré Mercier announced that the outbreak was under control. Thirty-one patients were diagnosed with Clostridium difficile and, as of November 18th, four were still under observation.

On February 27, 2007, an outbreak was identified at Trillium Health Centre in Mississauga Ontario, where 14 people were diagnosed with the bacteria, the same strain as the one in Quebec. Officials were not able to determine if C. difficile was responsible for deaths of four patients over the prior two months.